Department of Obstetrics and Gynecology

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Research Projects and Investigation

Projects Related to Obstetrics

RPI_photo_stack-325.jpgNuMOM2b Study

An NIH-funded cohort study of 10,000 women in their first pregnancy to look at biomarkers, genomics, and clinical parameters associated with adverse pregnancy outcomes of preterm birth, preeclampsia, fetal death, and fetal growth restriction. The goal is to develop better predictive algorithms and discover therapeutic targets to avoid adverse outcomes. (Haas)

NuMoM2b Heart Health Study

This NIH-funded study follows the nuMoM2b cohort looking at pregnancy as a window into future cardiovascular health. Women are seen for a study visit 2-5 years after their nuMoM2b delivery to look for cardiovascular disease and risk factors. (Haas)

NuMoM2b Heart Health Cardiovascular Fitness ancillary study

In this Heart Health ancillary study, women enrolled in Heart Health here at IU will be tested for physical activity with accelerometers and will also have true fitness testing on a treadmill. This study collaborates with investigators at NIFS and will correlate activity surveys with objective measures of physical activity and true physical fitness measures. (Haas)

NuMoM2b Sleep Disordered Breathing Substudy

This study analyzed sleep breathing and patterns during pregnancy in an effort to link them to adverse pregnancy outcomes. (Schubert, Haas)

Building Blocks of Pregnancy Biobank

Internally funded local pregnancy biobank. 1300 subjects were recruited with more than 28,000 samples banked. This is an observational pregnancy biobank. The goal is to provide a resource at IU for investigators to look for novel biomarkers and clinical variables associated with adverse pregnancy outcomes. (Haas)

Betamethasone and Estriol Study

An Internally funded study of women who are admitted with preterm labor who will be getting betamethasone to help accelerate fetal lung maturity. This study looks at maternal estriol as a potential biomarker of response to the drug, looking at associations with neonatal pulmonary function. We are collecting maternal blood and saliva and cord blood. There is also an optional pharmacokinetic component of the study. (Quinney, Haas)

Individualized Dosing of Nifedipine for Preterm Labor Tocolysis

A K23 (NIH)- funded study of women admitted for preterm labor who are given nifedipine to stop contractions. This is a pharmacokinetic study looking at how drug concentrations in the blood may impact the effectiveness of the drug at stopping preterm labor. (Quinney)

Glyburide and Metformin for Gestational Diabetes Mellitus (GDM)

An NIH-funded OPRU Network study RCT comparing the two drugs alone or in combination for women who have GDM and fail diet therapy before 32 weeks gestation. (Haas)

Predictors of Cesarean Delivery for Periviable Neonates (Tucker Edmonds)

This study looks at factors that contribute to cesarean delivery decisions and resuscitation decisions for parents and providers in the periviable period (23-25 weeks gestation).

Pravastatin for the Prevention of Preeclampsia in High-risk Women

An NIH-funded, (Phase 1 Pilot) FDA-regulated OPRU Network study of women recruited early in the pregnancy who had a prior preterm delivery < 34 weeks gestation because of preeclampsia. They are then randomized to pravastatin or placebo in this safety/efficacy study. (Haas)

Progestins for Preterm Birth Prevention Study

An NIH-funded OPRU Network study looking at progestin use in preterm birth prevention. This study recruits women in the early 2ndtrimester and follows them with study visits for 12 weeks. Procedures include vaginal fluid collection and ultrasounds. (Haas)

The Effect of Endogenous Fetal-derived Progestins on Human Myometrial Contractility

The goal of this research is to find hormones naturally produced by the fetus that can be used to identify or treat pregnancies at high risk of preterm birth. (Patil)

Team Optimization of Pregnancy (TOP) Program

The goal of this project is to reduce infant deaths and improve pregnancy outcomes in Marion County, Indiana through the implementation of a group prenatal care model. (Patil)

Nausea and Vomiting in Pregnancy (NVP) for Adolescents

This industry-sponsored study is testing the efficacy of FDA-approved Diclegis in an adolescent population. Placebo controlled RCT. (Haas)

Vitamin C for smoking pregnant women

This NIH-funded study is a placebo-controlled RCT for women who smoke in pregnancy comparing vitamin C and placebo for improving neonatal respiratory outcomes. This recruits women early in the pregnancy and follows them throughout. (Haas, Tepper)

Risk Perceptions, Worry, or Distrust: What Drives Pregnant Women's Decision to Accept the H1B1 vaccine?(Tucker Edmonds)
Racial and Ethnic Differences in Utilization of Intubation for Periviable Neonates(Tucker Edmonds)
IMPROVE Study

This study is an internally funded RCT comparing vaginal to buccal misoprostol in cervical ripening/labor induction, combining PK parameters to clinical efficacy. (Haas, Quinney, Morgan, Bonsack, Lathrop)

Sleep disorders and lactation

This study of first time mothers, done in collaboration with investigators at Purdue, recruits women in the first trimester and evaluates their sleep patterns in pregnancy and the impact on lactation after birth. (Haas)

Prenatal Care Study

This study is done in collaboration with investigators at IU Bloomington and is funded by the ISDH to look at incentives to aid in efforts to have women stop smoking in pregnancy. (Haas)

Methadone PK and infant outcomes

This study looks at PK and pharmacogenetics of methadone in pregnant women and their correlation to neonatal abstinence syndrome. (Quinney)

Projects Related to Gynecology
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction and Insulin Resistance

A double-blind study, placebo controlled clinical atrial which aims to characterize the molecular mechanism by which dietary components such as lipid and glucose exacerbate low-grade inflammation in PCOS and the ability of a non-steroidal anti-inflammatory agent to decrease ovarian androgen secretion and improve insulin sensitivity by reducing inflammation. (Gonzalez)

Role of immune Cell OGR1 in Prostate Cancer Development and the Mechanisms Involved

This research is part of a focus on the understanding, at the molecular level, the mechanisms responsible for the development of ovarian, prostate, colorectal, and other malignancies. This laboratory work pioneered research in the role of lipid signaling molecules in ovarian cancer and identified the first lipid growth factor I ovarian cancer cells. (Xu)

Moving Beyond the Impasse: Discussing Death and Dying with African American Patients (Tucker Edmonds)

 

Levator Ani Muscle Morphology and Innervation in Patients with Prior Abdominal vs. Vaginal Hysterectomy. (Heit)

 

Retrospective Analysis of the Use of AllodermÒfor the surgical treatment of stress incontinence (Heit)

 

A Prospective, Non-Randomized , Parallel Cohort, Multi-center Study of the Solyx Single Incision Sling System vs the Obtryx II Sling System for the Treatment of Women with Stress Urinary Incontinence

A multicenter Trial sponsored by Boston Scientific (Hale)

Complete Continence as Primary Metric for Onabotulinumtoxin A Overactive Bladder Treatment Success

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study in Overactive Bladder Patients with Urinary Incontinence (Hale)

Gynecologic Oncology Group Clinical Trials (Stehman)

 

Can Diet and Physical Activity Modulate Ovarian, Fallopian Tube and Primary Peritoneal

Cancer Progression-Free Survival?

A Randomized Trial of Pelvic Irradiation with or Without Concurrent Weekly Cisplatin in Patients with Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus

Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Llymphadenectomy

A Randomized Phase II/III Study to Assess the Efficacy of Trametinib (GSK 1120112) in Patients with Recurrent or Progressive Low-Grade Serous Ovarian Cancer or Peritoneal Cancer.

A Phase II Trial of DCTD-Sponsored Dastinib (NSC #7532517 IND #120636 in Recurrent/Persistent Ovary, Fallopian Tube, Primary Peritoneal, and Endometrial Clear Cell Carcinoma Characterized for the Retention of Loss of BAF25a Expression

A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NNSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer.

A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel Alone or in Combination with Bevacizumab (NSC #704865, IND #7921) Followed by Bevacizumab and Secondary Cytoreductive Surgery I Platinum-sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer, NCI-Suplied agents: BEVACIZUMAB (NSC #704865 IND#7921.

A Phase III Trial of Adjuvant Chemotherapy Following Chemoradiation as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: The OUTBACK Trial.

A Phase II Trial Evaluating Cisiplatin (NSC #119875) and Gemcitabine (NSC #613327) Concurent with Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Locally Advanced Squamous Cell Carcinoma of the Vulva.

Indiana University School of Medicine
Department of Obstetrics and Gynecology
550 University Blvd
Indianapolis, IN 46202


obgyniu@iupui.edu

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