Department of Obstetrics and Gynecology

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Research Projects

  1. The Building Blocks of Pregnancy BiobankThis study established a longitudinal pregnancy biorepository at IUSM. Specimens are collected throughout pregnancy and at delivery and are paired with robust clinical outcome and covariate data. These specimens and data will serve as a resource for multiple studies analyzing the genetics and biomarkers for adverse pregnancy outcomes.
  2. The pharmacogenetics of antenatal corticosteroidsThis project examines genetic variation in pregnant women and newborns as a source of differences in neonatal response to steroids given to pregnant women to help mature the baby's lung more rapidly.
  3. The pharmacokinetics and pharmacogenetics of nifedipine for preterm labor tocolysisThe objective of this project is to characterize the blood concentrations or levels of nifedipine in pregnant women when used to help stop preterm labor. In addition, we will test for association between known genetic changes in the enzymes that metabolize nifedipine and other enzymes and transporters potentially involved in how women handle nifedipine and its efficacy during pregnancy.
  4. A pharmacogenetic study of vincristine neurotoxicity in pediatric patients with malignanciesThis objective of this project is to identify genetic variations that predispose patients receiving vincristine chemotherapy to various toxicities and/or efficacy.
  5. NuMoM2b- Monitoring outcomes for nulliparous pregnant women- This cohort study of 10,000 women across the country has collected robust clinical, ultrasound, psychosocial, and biospecimens data from first-time pregnant women with an aim to better predict adverse pregnancy outcomes such as preterm birth, preeclampsia, stillbirth, and fetal growth restriction.
  6. Pregnancy as a window to future cardiovascular health- NuMoM2b Heart Health Study- The goal of this project is to define the relationship between adverse pregnancy outcomes and markers of cardiovascular disease risk at two years post-delivery.
  7. OPRU Glyburide and Metformin for GDM trial- This randomized trial of oral therapies for women who need treatment for gestational diabetes is being carried out in 4 sites nationally. This is designed to identify the best therapy to obtain adequate glucose control and to determine reasons why certain drugs may fail.
  8. OPRU Progestin study- This study looks at several groups of women at risk for preterm birth in an effort to determine the impact of progestin therapy on the cervix, utilizing cuttine-edge proteomic and ultrasonographic data points.
  9. OPRU Statin study- This study examines the use of pravastatin in women with a history of prior severe preeclampsia requiring preterm delivery. The goal is to characterize the pharmacokinetics and safety of the drug in this Phase I study.
  10. Centering Pregnancy care model for High-Risk pregnant women- This is an ongoing evaluation of our tailored program of group prenatal care specifically for the high-risk group of Hispanic women with gestational diabetes looking at pregnancy and health outcomes. In addition, with funding from the March of Dimes, we are evaluating the impact of Centering group care on other high risk groups, beginning with women with a prior preterm birth.
  11. Myometrial contractility and the impact of progestin- This is a translational study looking at the mechanisms of action of progestins regarding smooth muscle.
  12. Depression screening in pregnant women with medical comorbidities- This project looks at the impact of different medical complications in pregnancy as risk factors for mental health disorders including depression.
  13. Environmental toxins and endocrine disruptors and the impact on reproductive outcomes- This encompasses several studies on the impact of various environmental compounds on reproductive and pregnancy outcomes.
  14. Circulating progenitor cells as mediators of disease- This is a series of studies looking at the impact of pregnancy conditions and treatments on circulating progenitor cells and how they are impacted in the fetus and neonate and may correlate to childhood diseases.
  15. IMPROVE Study- This study will be an RCT comparing buccal to vaginal dosing of misoprostol for labor induction. This study will incorporate PK parameters to build a therapeutic model and will incorporate patient preference measures.

Indiana University School of Medicine
Department of Obstetrics and Gynecology
550 University Blvd
Indianapolis, IN 46202

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