Department of Obstetrics and Gynecology

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Yan Xu, PhD

Xu1.jpgYan Xu, PhD

Professor The Hulman-George Family Professor of Gynecologic Cancer
Department of Obstetrics and Gynecology

Clinical Section: Gynecologic Oncology

Graduate: PhD, Biochemistry, State University of New York at Albany, 1988

Undergraduate: Biology, Beijing Normal University, P.R. China, 1982

E-mail: Xu2@iupui.edu

Address: 975 W. Walnut, IB 355A
Indianapolis, IN 46202

Pub Med Search: http://www.ncbi.nlm.nih.gov/pubmed/?term=Xu+Y

IU Research Connect: http://www.experts.scival.com/indiana/default.asp

Research Interests:

My main research interests deal with understanding at the molecular level the mechanism of development and progress of the molecular aspects of ovarian, prostate, colon and other cancers. In particular, we are interested in tumor microenvironment and metastasis, as well as anoikis-resistance. These include developing effective diagnostic and prognostic biomarkers for these diseases, studying signaling mechanistic studies, identifying novel therapeutic targets and methods to treat them. Several mouse models have been established or are under development to address mechanisms underlying tumor initiation, progression, and metastasis.

Current Programs:

 

  1. Tumor metastasis and microenvironment Mouse models of ovarian cancer
  2. Anoikis-resistance in ovarian cancer
  3. Role of lysophospholipids in ovarian cancer
  4. Development of diagnostic and prognostic markers for ovarian and other cancers G protein coupled receptors for bioactive lysophospholipids and their signaling pathways

 


Collaborators:

Li Zhang, professor, Toronto General Research Institute, University of Toronto. Liang Cheng, Professor of Pathology and Urology, Indiana University School of Medicine (IUSM). Randy R. Brutkiewicz, Ph.D. Professor of Microbiology and Immunology, IUSM.
Kao, Chinghai, Associate Professor, Thomson Scholar of Prostate Cancer Research, IUSM
Piccirillo, Ciriaco A., Associate professor, Department of Microbiology and Immunology, McGill University, Faculty of Medicine Center for the Study of Host resistance, MUHC.
Jinwu Xie, Jonathan and Jennifer Simmons Professor of Pediatrics, Department of Pediatrics, IUSM.
Zhong-yin Zhang, Robert A. Harris Professor and Chairman, Department of Biochemistry and Molecular Biology, IUSM.
Liangpunsakul, Suthat, Associate Professor of Medicine, Adjunct Associate Professor in Public Health. IUSM.
Ken Nephew, Professor, Indiana University School of Medicine, Bloomington, IN, USA.
Mircea Ivan, Associate Professor,

Department of Medicine, Division of Hematology/

Oncology IU School of Medicine.

Indiana University School of Medicine
Department of Obstetrics and Gynecology
550 University Blvd
Indianapolis, IN 46202


obgyniu@iupui.edu

A gift to the department of Obstetrics and Gynecology can be made online through our Gift Development Department or through the mail with a linked PDF Form.

 

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