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David M. Haas, MD, MS

12914110233_8qtrK1.jpgDavid M. Haas, MD, MS

Associate Professor of Obstetrics and Gynecology

Clinical Section: General Obstetrics and Gynecology
Maternal Fetal Medicine

Graduate: MS, Clinical Research,
Indiana University, 2008

Residency: Naval Medical Center, 2001

MD: St. Louis University, 1997

Undergraduate: University of Notre Dame, 1993

E-mail: dahaas@iu.edu

Address: Eskenazi Hospital
740 Eskenazi Avenue
Indianapolis, IN 46202

Pub Med : http://www.ncbi.nlm.nih.gov/pubmed/?term=Haas%2C+DM

IU Research Connect: http://www.experts.scival/com/indiana/default.asp

Research Interests:

I have a keen interest in studying medications in pregnancy. An initial particular area of focus was in the area of antenatal corticosteroids – particularly trying to optimize betamethasone dosing to improve neonatal outcomes. This early clinical research of a cohort of pregnant women with threatened preterm birth served as a launching pad to research into betamethasone dosing and outcomes. This line of research continues as we search for biomarkers of fetal response to betamethasone that can guide clinicians to individualize this therapy in pregnancy.

Stemming from this early work with betamethasone pharmacogenetics, I began collaboratively researching individualized pharmacotherapy in pregnancy. This led to the development of PREGMED: The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health which became a funded site of the NICHD Obstetric-Fetal Pharmacology Research Units (OPRU) Network. We have focused on pharmacogenetic analyses for several drugs in pregnancy and have expertise as the main site for these analyses for all the OPRU-funded trials.

I also lead the IUSM site in both the NICHD funded nuMoM2b Network and the NHLBI-funded nuMoM2b Heart Health Study, aimed at revealing how adverse outcomes and occurrences in the first pregnancy can serve as a window to a woman’s future cardiovascular health.

Current/Recent Research Funding:

1U10 HL119990-01 Haas, DM (PI) 07/01/2013 – 06/30/2017

NIH/NHLBI

Pregnancy as a window to future cardiovascular health

The goal of this project is to define the relationship between adverse pregnancy outcomes and markers of cardiovascular disease risk at two years post-delivery. This is a multicenter study that will utilize an ethnically, racially, socioeconomically and geographically diverse cohort of 10,000 nulliparous women enrolled in the NICHD-funded Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMOM2b).

Role: PI

3 U10 HD063037-03S1 Haas, DM (PI) 01/10/2010 – 12/31/2014

NIH/NICHD

Dissecting the genetic etiology of preterm birth in nulliparous women

The major goals of this project is to identify a series of DNA polymorphisms and physiologic biomarkers that will improve the understanding of the disease and will identify the subset of nulliparous women at greatest risk for early preterm which would allow for targeted intervention or the institution of preventative measures and strategies for this high-risk group.

Role: PI

5 U10 HD063094-03 Flockhart, DA (PI) 02/01/2010 – 12/31/2015

NIH/NICHD

Indiana PREGMED

The major goals of this project are to develop an Obstetric Pharmacology Research Unit which will bring together skills and technologies that have been key to the therapeutic revolution to the study of therapeutics in pregnancy.

Role: Clinical Co-PI

5 R01 HL105549-02 Zee, P (PI) 06/01/2011 – 04/30/2014

NIH/NHLBI

Sleep disturbance and the risk for adverse pregnancy outcomes

The overall hypothesis to be tested is that sleep disturbances are associated with an increased risk for cardiometabolic disorders during pregnancy. Specifically this application proposes to evaluate self-reported and objective sleep/wake characteristics in a large cohort of pregnant women from who detailed cardiovascular and metabolic pregnancy outcomes will be measured from the first trimester to delivery.

Role: Site PI

1R01 HL105447-01A1 McEvoy, C (PI) 07/15/2012 – 05/31/2017

NIH/NHLBI

Vitamin C to decrease effects of smoking in pregnancy on infant lung function

The purpose of this study is to determine whether extra daily vitamin C taken by pregnant women who cannot quit smoking, can block the negative effects of the smoking on the baby’s lung development as shown by how the baby’s lungs work after delivery

Role: Co-Investigator

Grant # PED-301 Haas, DM (Site PI) 08/06/3013 – 12/31/2014

Duchesnay Pharmaceutical, Inc.

Title: A Multicenter Trial Comparing the Efficacy and Safety of Diclegis® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents

The primary objective of this randomized, placebo-controlled trial is to demonstrate efficacy and safety of Diclegis in the treatment of NVP in adolescent women.

Other current research projects:

  • The Building Blocks of Pregnancy Biobank: This project prospectively collected specimens from pregnant women throughout pregnancy and at the time of delivery. The bank currently consists of over 1300 women and their babies. The aim of the project is to serve as a collaborative resource for determining biomarkers of adverse pregnancy outcomes to serve as potential diagnostic or therapeutic targets.
  • Betamethasone projects: We have multiple studies regarding antenatal corticosteroids looking at biomarkers of fetal response, objective measures of newborn lunch compliance, and pharmacogenetics of dosing.
  • IMPROVE Study: This is a randomized placebo controlled trial looking at different ways to administer misoprostol for labor induction. We are uniquely adding pharmacokinetics to the aims of the project to truly look at reasons for response or failed response.
  • Sleep disorders and lactation: We are collaborating to recruit women to see if sleep disorders impact the ability to successfully breastfeed.
  • Preterm birth studies: We continue to be actively involved in research into preterm birth, participating in collaborative trials and systematic reviews synthesizing evidence.
  • Centering Pregnancy projects: We have developed a specialized group prenatal care model in conjunction with Centering Pregnancy for Hispanic GDM women to ascertain if outcomes are improved in this model of care.

Indiana University School of Medicine
Department of Obstetrics and Gynecology
550 University Blvd
Indianapolis, IN 46202


obgyniu@iupui.edu

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