Department of Obstetrics and Gynecology

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Reproductive Endocrinology and Infertility

Welcome to the Division of Reproductive Endocrinology and Infertility

The Reproductive Endocrinology Division is currently composed of two Reproductive Endocrinologists, Dr. Frank González and Dr. Marguerite Shepard and a full time Nurse Practitioner. Two additional Reproductive Endocrinologists serve as Volunteer Faculty members to support the educational, clinical and research missions of the Division. These board-certified faculty physicians provide inpatient and outpatient consultation with the full range of procedural services that include the assisted reproductive technologies with the support of the Center for Reproductive Biology of Indiana.

Our Team

Volunteer Faculty
  • William Gentry, M.D.
  • Michael Henry, M.D.

Tripartite Mission

The Reproductive Endocrinology Division is actively involved in each of the Department of Obstetrics and Gynecology’s clinical, research and educational missions, striving to bring evidence-based, compassionate, quality care to the women of Indiana.


The Division provides in-depth exposure to the field of Reproductive Endocrinology and Infertility to residents and medical students. Trainees receive considerable ambulatory experience in the evaluation and treatment of infertility, and the management of reproductive endocrine disorders associated with ovarian dysfunction such as amenorrhea, abnormal uterine bleeding, galactorrhea, hisrsutism and polycystic ovary syndrome (PCOS). Training is also provided in advanced operative endoscopy and microsurgery at IU Hospital and the Beltway North Surgery Center.


The Division is involved in on-going clinical research aimed at optimizing diagnostic capabilities in the management of infertility and PCOS, and improving health outcomes in the field of in vitro fertizilation (IVF).

Our Clinical Strengths and Expertise

The division offers a full range of diagnostic and treatment options for the women of Indiana. The physicians will work with the patient to determine the best management approach. Some of the services include:

Evaluation and Treatment for Endocrine Disorders
  • Abnormal Uterine Bleeding
  • Amenorrhea- A condition in which there is an absence of menstrual periods in a woman
  • Galactorrhea- The spontaneous flow of milk from the nipple at any time other than during nursing.
  • Premenstrual Syndrome (PMS)- a combination of physical and emotional disturbances associated with the menstruation
  • Dysmenorrhea- Pain or discomfort associated with menstruation
Ovulation Induction

Women may have problems with ovulation that prevent them from becoming pregnant. These problems may be treated with either pills or injections that stimulate the ovaries thus increasing the possibility of ovulation and pregnancy.

Medical and Surgical Treatment for Endometriosis

Endometriosis, a condition in which uterine lining tissue is found outside the uterus, most often on the ovaries or the interior walls of the pelvic cavity, can cause pelvic pain or impede the ability to become pregnant. A number of treatment options are available for endometriosis including hormonal medications and laparoscopic or general surgery. Individualized treatment is offered with the goal of optimizing patient care.

Artificial Insemination

Artificial Insemination is an outpatient procedure in which the male partner's sperm or donor sperm is washed and placed in a woman's uterus to assist the fertilization process. This approach is used when the sperm count or sperm motility is low, or a woman has poor cervical mucus.

In Vitro Fertilization (IVF) with or without Intracytoplasmic Sperm Injection (ICSI)

With in-vitro fertilization, a couple’s sperm and eggs are harvested, and the eggs are fertilized outside the body in a lab dish. If sperm motility is decreased or absent, the sperm may be injected directly into the eggs using a micromanipulation procedure called ICSI. Fertilized embryos are subsequently transferred to the woman’s uterus. Pregnancy can result in up to 50% of cases but the results vary depending on the age of the female partner, the previous pregnancy history and the quality of the embryos to be transferred.

The center for Reproductive Biology of Indiana provides support to perform IVF and ICSI along with additional assisted reproductive that include preimplantation genetic diagnosis (PGD), cryopreservation (freezing) of eggs, sperm and embryos, egg donation and fertility preservation for male and female cancer patients.

Tubal Ligation Reversal

Many women have a tubal ligation when they believe that they are finished having children. If a woman then subsequently decides that she would like to have another child, the tubal ligation can be reversed in many instances. A Reproductive Endocrinologist at IU Women’s Healthcare trained to perform tubal reconstruction can evaluate a woman to assist her in determining the benefits and drawbacks of reversing her tubal ligation. Tubal microsurgery is available to provide a patient with the possibility to once again have children.

Treatment of Polycystic Ovary Syndrome

Polycystic Ovary Sydrome (PCOS) is a condition characterized by a hormone imbalance leading to ovarian dysfunction and results in menstrual disturbance (e.q. infrequent or absent periods; prolonged periods) and lack of ovulation. Consequently, PCOS is the most common cause of female infertility. As a result of the hormonal imbalnce, women with PCOS often have excessive facial or body hair, acne beyond adolescence or scalp hair loss. Metabolic abnormalities such as insulin resistance and high cholesterol that predispose to diabetes and cardiovascular disease are often present in PCOS. A comprehensive evaluation is offered to diagnose PCOS and a number of treatment are available to improve hormonal and metabolic status, regulate menstrual periods, control excess hair or acne and induce ovulation for fertility.

To Contact us:

Division of Reproductive Endocrinology
Marguerite Shepard, M.D.
Division Director

For office numbers and sites where you can receive care, please access:

Indiana University School of Medicine
Department of Obstetrics and Gynecology
550 University Blvd
Indianapolis, IN 46202

A gift to the department of Obstetrics and Gynecology can be made online through our Gift Development Department or through the mail with a linked PDF Form.


Thank you for making a difference!

For information about the various ways to give or on unique procedures we perform, please contact us at 317-944-8609.